Title : Hierarchical cortical transcriptome disorganization in autism
نویسندگان
چکیده
Affiliations 1 Center for Applied Neuroscience, Department of Psychology, University of Cyprus, Nicosia, Cyprus 2 Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom 3 Department of Neuroscience, University of California, San Diego, San Diego CA, USA 4 Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, USA 5 Novo Nordisk Foundation Center for Biosustainability at the University of California, San Diego, La Jolla, CA, USA
منابع مشابه
Hierarchical cortical transcriptome disorganization in autism
BACKGROUND Autism spectrum disorders (ASD) are etiologically heterogeneous and complex. Functional genomics work has begun to identify a diverse array of dysregulated transcriptomic programs (e.g., synaptic, immune, cell cycle, DNA damage, WNT signaling, cortical patterning and differentiation) potentially involved in ASD brain abnormalities during childhood and adulthood. However, it remains u...
متن کاملPatches of disorganization in the neocortex of children with autism.
BACKGROUND Autism involves early brain overgrowth and dysfunction, which is most strongly evident in the prefrontal cortex. As assessed on pathological analysis, an excess of neurons in the prefrontal cortex among children with autism signals a disturbance in prenatal development and may be concomitant with abnormal cell type and laminar development. METHODS To systematically examine neocorti...
متن کاملTitle: Maternal immune activation dysregulation of the fetal brain transcriptome and relevance to the pathophysiology of autism spectrum disorder
1 Centre for Integrative Neuroscience and Neurodynamics, School of Psychology and Clinical Language Sciences, University of Reading, Reading, UK 2 Center for Applied Neuroscience, Department of Psychology, University of Cyprus, Nicosia, Cyprus 3 Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK 4 Department of Neurosurgery, Institute for Stem Cell Biology ...
متن کاملAttachment security in infants at-risk for autism spectrum disorders.
Little is known about attachment security and disorganization in children who are at genetic risk for an Autism Spectrum Disorder (ASD) prior to a possible diagnosis. The present study examined distributions of attachment security and disorganization at 15-months of age in a sample of infant siblings of older children with (ASD-sibs; n = 51) or without (COMP-sibs; n = 34) an ASD. ASD-sibs were ...
متن کاملCytoplasmic Rbfox1 Regulates the Expression of Synaptic and Autism-Related Genes
Human genetic studies have identified the neuronal RNA binding protein, Rbfox1, as a candidate gene for autism spectrum disorders. While Rbfox1 functions as a splicing regulator in the nucleus, it is also alternatively spliced to produce cytoplasmic isoforms. To investigate the function of cytoplasmic Rbfox1, we knocked down Rbfox proteins in mouse neurons and rescued with cytoplasmic or nuclea...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2016